การรักษาด้วยเคมีบำบัด (Chemotherapy)

Chemotherapy – Karaca H, Bozkurt O, etc., “Positive effects of oral B-glucan on mucositis and leukopenia in colorectal cancer patients receiving adjuvant FLFOX-4 combination chemotherapy.” Asian Pac J Cancer Prev, 2014;15(8):3641-4, PMID 24870771. Quote: “Oral mucositis and diarrhea were less common in the B-glucan group.  We conclude that B-glucan can be used to reduce the adverse effects of chemotherapy. “ [Mucositis is the painful inflammation and ulceration of the mucous membranes lining the digestive tract-an adverse effect of chemotherapy and radiotherapy treatment for cancer.]

Chemotherapy: Hofer M, Pospisil M, “Modulation of animal and human hematopoiesis by B-glucans: a review.” Molecules, Sep 15;16(9): 7969-79. PubMed 21921869. 2011. Quote: “B-glucans have been shown to support murine hematopoiesis suppressed by ionizing radiation or cytotoxic anti-cancer therapy [chemotherapy]. They also enhance stem cell homing and engraftment.  Note: “Hematopoiesis” is the process of creating new blood cells in the body. All blood cells start off as hematopoietic stem cells, and then specialize or differentiate into myeloid cells including erythrocytes, megakaryocytes, monocytes, neutrophils, basophils, or eosinophils; or lymphoid cells including T-lymphocytes and B-lymphocytes.

Chemotherapy – Zechner-Krpan V, Petravic-Tominac V, GrBa Slobodan, Pnaikota-Krbavcic I, Vidovic L, “Biological Effects of Yeast B-Glucans,” Agriculturae Conspectus Scientificus, 2010, Vol 75, No.4 (149-158). Quote: B-Glucans work, in part, by stimulating the innate immune mechanism to fight a range of foreign challenges and could be used as an adjuvant, in combination with anti-infective or antineoplastic agents, radiotherapy, an a range of topical agents and nutrients.” [Note: “antineoplastic agents” inhibit the maturation and proliferation of malignant cells including chemotherapy drugs]

Chemotherapy: “The Biological activity of beta-glucans”; Minerva Medical; 100(3):237-245; Pub Med 19571787;  Jun 2009; Quote: “…Beta-glucans have studied for their hypocholesterolemic effects; these mechanisms include: reducing the intestinal absorption of cholesterol and bile acids by binding to glucans; shifting the liver from cholesterol syntheses to bile acid production; and fermentation by intestinal bacteria to short-chain fatty acids, which are absorbed and inhibit hepatic cholesterol syntheses. …beta-1,3-glucans improve the body’s immune system defense against foreign invaders by enhancing the ability of macrophages, neutrophils and natural killer cells to respond to and fight a wide range of challenges such as bacteria, viruses, fungi, and parasites. …there is renewed interest in the potential usefulness of beta-glucan as a radioprotective drug for chemotherapy, radiation therapy and nuclear emergencies, particularly because glucan can be used not only as a treatment, but also as a prophylactic [taken in advance for protection].”

Chemotherapy-cyclophosphamide: Kogan G, Pajtinka M, Babincova M, Miadokova E, Rauko P, Slamenova D, Korolenko TA; “Yeast cell wall polysaccharides as antioxidants and antimutagens: can they fight cancer?” Inst of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia; Neoplasma 55(5):387-93 2008. Quote: “…yeast cell wall beta-D glucans reveal immunomodulating properties which allows for their application in anti-infective and antitumor therapy.The derivatives of beta-D-glucan exerted potent enhancement of tumor necrosis [killing] factor alpha (TNF-alpha) …and revealed synergistic effect with cyclophosphamide in the treatment of Lewis lung carcinoma and two types of lymphosarcoma in murine models. The results indicate protective antioxidant, antimutagenic  and antigenotoxic [deters physical dna damage] activities…and imply their potential application in anticancer prevention/therapy.”

Chemotherapy: Akramiene D, Kondrotas A, Didziapetriene J, Kevelaitis E; “Effects of beta-glucans on the immune system.” Medicina (Kaunas). Dept of Physiology, Kaunas U of Medicine, Kaunas, Lithunia. 43(8):597-606; 2007. Quote: “Beta-glucans are naturally occurring polysaccharides….These substances increase host immune defense by activating complement system, enhancing macrophages and natural killer cell function.  beta-Glucans also show anticarcinogenic activity. They can prevent oncogenesis due to the protective effect against potent genotoxic carcinogens [chemotherapy components]. As immunostimulating agent, which acts through the activation of macrophages and NK cell cytotoxicity, beta-glucan can inhibit tumor growth…reduce tumor proliferation, prevent tumor metastasis. beta-Glucan as adjuvant to cancer chemotherapy and radiotherapy demonstrated the positive role in the restoration of hematopiesis [red blood cells] following by bone marrow injury. 

Chemotherapy: Sener G, Eksioglu-Demiraop E, Cetiner M, Ercan F, Yegen BC;  “beta-glucan ameliorates methotrexate-induced oxidative organ injury via its antioxidant and immunomodulatory effects.” European J Pharmacology; 542(1-3):170-178; Epub May 2006. Aug 7 2006. Quote: “Methotrexate is an antifolate [antimetabolite chemotherapy drug] that is widely used in the treatment of rheumatic disorders and malignant tumors. The efficacy of methotrexate is often limited by severe side effects and toxic sequelae [disease condition caused by a disease], where oxidative stress[free radical damage] is noticeable. … Thus, the findings of the present study suggest that beta-glucan, through its antioxidant and immunoregulatory effects, may be of therapeutic value in alleviating the leukocyte apoptosis [white immune cell death], oxidative [free radical] tissue injury and thereby the intestinal and hepatorenal [liver or kidney] side effects of methotrexate treatment.”

Chemotherapy: Tohamy AA et al. “Beta-glucan inhibits the genotoxicity of cyclophosphamide, adriamycin and cisplatin.” Mutat. Research. 541(1-2):45-53. Nov 2003. Quote: “This protective effect of beta-glucan could be attributed to its scavenging ability to trap free-radicals produced during the biotransformation of these anti-neoplastic [abnormal tissue growth] drugs. Beta-glucan also markedly restored the mitotic [cell division] activity of bone marrow cells that had been suppressed by the anti-neoplastic drugs. These results indicate that in addition to known immunopotentiating activity of beta-glucan, it plays a role in reducing genotoxicity [capability to cause cancer] induced by anti-neoplastic [abnormal tissue growth] drugs during cancer chemotherapy.”

Chemotherapy: Carrow, D.J. M.D.; “Beta-1,3-glucan as a Primary Immune Activator,” Townsend  Letter; June 1996. Quote: “The following list includes benefits from the use of Beta 1,3-glucan supplementation: People who have impaired immunity from any cause …; have a high occurrence of infectious diseases; have tumors and/or those undergoing chemotherapy or radiation therapy; are over forty who are concerned about the natural aging process or might have noticed a slowing down of immune reactivity; who are geriatric patients; and other with compromised immune disorders.”

Chemotherapy: Damia, et al, “Prevention of Acute Chemotherapy-Induced Death in Mice by Recombinate Human Interleukin 1: Protection from Hematological and Nonhematological Toxicities”, Cancer Research, vol. 52, pp. 4082-4089.

Chemotherapy – Leukemia: Stewart C.C., et al., “Preliminary Observations on the Effect of Glucan in Combination with Radiation and Chemotherapy in Four Murine Tumors”, Cancer Treat. Prep.; 62: 1867-72. 1978. Quote“The efficacy of glucan in combination with BCNU chemotherapy was measured using the disseminated AKR transplantable leukemia; the combination yielded a high level of cures compared to no survival for either agent alone.”


 

Comments are closed.