การรักษาแผลต่างๆ และ ทำให้แผลหายเร็ว (Healing)

Ulcers – DecubitusBrowder I.W., DiLuzio N.R., et al. “Enhanced Healing of Decubitus Ulcers by Topical Application of Particulate Glucan.” Tulane University School of Medicine; Research Summary. 1984.

Ulcers, Pressure – Sener G, Sert G, Ozer SA, Arbak S, Uslu B, Gedik N, Avanoglu-Dulger G; “Pressure ulcer-induced oxidative organ injury is ameliorated by beta-glucan treatment in rats.” Int Immunopharmacol:6(5):724-32; Marmara U, Sch of Pharmacy, Dept Pharmacology, Div Biochemistry; Epub Nov 2005; May 2006. Quote: Pressure ulcers (PU) cause morphological and functional alterations in the skin and visceral organs. … Local treatment with beta-glucan inhibited the increase in MDA and MPO levels and the decrease in GSH in the skin induced by (PU),   … systemic treatment prevented the damage in the visceral organs. Significant increases in creatinine, BUN, ALT, AST, LDH and collagen levels in PU [Pressure Ulcers] group were prevented by beta-glucan treatment. …Tissue injury was decreased. …Thus, supplementing geriatric and neurologically impaired patients with adjuvant therapy of beta-glucan may have some benefits for successful therapy and improving quality of life.”

Ulcers – Venous: Medeiros SD et al; “Effects of Purified Saccharomyces cerevisiae (1-3)-B-Glucan on Venous Ulcer Healing;”  Laboratory of Clinical Immunology, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte (UFRN), General Gustavo Cordeiro de Farias Ave., Petrópolis, Natal, RN 59012-570, Brazil; Int J Mol Sci. 2012;13(7):8142-58. Epub 2012 Jul 2. Quote: “The effects of the glucan on wound healing were assessed in human venous ulcers by histopathological analysis after 30 days of topical treatment. (13)-β-glucan enhanced ulcer healing and increased epithelial hyperplasia, as well as increased inflammatory cells, angiogenesis and fibroblast proliferation. In one patient who had an ulcer that would not heal for over 15 years, glucan treatment caused a 67.8% decrease in the area of the ulcer. This is the first study to investigate the effects of (13)-β-glucan on venous ulcer healing in humans; our findings suggest that this glucan is a potential natural biological response modifier in wound healing.”

Wound Healing: Medeiros SD et al; “Effects of Purified Saccharomyces cerevisiae (1-3)-B-Glucan on Venous Ulcer Healing;”  Laboratory of Clinical Immunology, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte (UFRN), General Gustavo Cordeiro de Farias Ave., Petrópolis, Natal, RN 59012-570, Brazil; Int J Mol Sci. 2012;13(7):8142-58. Epub 2012 Jul 2. Quote: “The effects of the glucan on wound healing were assessed in human venous ulcers by histopathological analysis after 30 days of topical treatment. (13)-β-glucan enhanced ulcer healing and increased epithelial hyperplasia, as well as increased inflammatory cells, angiogenesis and fibroblast proliferation. In one patient who had an ulcer that would not heal for over 15 years, glucan treatment caused a 67.8% decrease in the area of the ulcer. This is the first study to investigate the effects of (13)-β-glucan on venous ulcer healing in humans; our findings suggest that this glucan is a potential natural biological response modifier in wound healing.”

Wound Healing: Chen J, Raymond K, “Beta-glucans in the treatment of diabetes and associated cardiovascular risks,” Vascular Health Risk Management, 4(6): 1265-1272; Dec 2008. QuoteManagement of diabetes includes: control of blood glucose level and lipids; and reduction of hypertension. Dietary intake of beta-glucans has been shown to reduce all these risk factors to benefit the treatment of diabetes and associated complications.  In addition, beta-glucans also promote wound healing and alleviate ischemic heart injury.”

Wound Healing: Berdal M, Appelbom HI, Eikrem JH et al: “Aminated B-1-3-D-glucan has dose-dependent effect on wound healing in diabetic db/db mice.” 2011 Sep-Oct;19(5):579-87. doi: 10.1111/j.1524-475X.2011.00715.x.. Quote: Inflammatory responses are common in diabetes and are operative in angiopathy, neuropathy, and wound healing. There are indications of incomplete macrophage activation in diabetes and reduced expression of growth factors. We have previously found that up to 15 topical applications of the macrophage-stimulant, aminated β-1,3-D-glucan (AG), improved wound healing in db/db mice.

Wound Healing – Zechner-Krpan V, Petravic-Tominac V, GrBa Slobodan, Pnaikota-Krbavcic I, Vidovic L, “Biological Effects of Yeast B-Glucans,” Agriculturae Conspectus Scientificus, 2010, Vol 75, No.4 (149-158). Quote: “Immunomodulation by B-glucan, both in vitro and in vivo, inhibits cancer cell growth and metastasis and prevents bacterial infection. In humans, dietary B-glucan lowers blood cholesterol, improves glucose utilization by body cells and also helps wound healing.”

Wound Healing: Jamas S, Easson D, Ostroff G: “Underivatilized aqueous soluble beta (1,3) glucan, composition and method of making same.” U.S. Patent Application 20020032170, March 14, 2002. Quote: Beta-glucan was shown to be beneficial in animal models of trauma, wound healing and tumorigenesis.”

Wound  Healing: Browder IW., Williams D., Lucor P., Pretus H., McNamee R., Jones E., “Effect of enhanced macrophage function on early wound healing,” Surgery, 104:224-230,  1988.

Wound Healing: Kaplan J.; “Acceleration of Wound Healing by a Live Yeast Cell Derivative”.  Archives and Surgery”, Sep. 1984; 119:1005-1008. 1984.

Wound Healing: Leibovich S.J., et al., “Promotion of Wound Repair in Mice by Application of Glucan”.  J. Reticuloendothel, Soc. 27: 1-11. 1980. Quote: “Of all the substances tested, glucan was the only substance to exhibit a particularly marked enhancement of the proliferative phase of wound healing.  It appears, from these experiments, that the effect observed by others in terms of the activation of reticuloendothelial [immune response] function by glucan and the activation of macrophages, both locally and systematically, also apply to activation of macrophages in healing wounds.”

Wound Healing: Lehtovaara BC, Gu FX; “Pharmacological, Structural, and Drug Delivery Properties and Applications of 1,3-B-Glucans,” Dept of Chem Eng, U of Waterloo, Ontario, Canada; J Agric Food Chem, Jun 7 2011.  PMID 21609131. Quote: “The pharmacological capabilities of 1,3-B-glucans include the impartation of tumor inhibition, resistance to infectious disease, and improvements in wound healing.”

Wound Healing: Portera CA, Love EJ, Memore L, Zhang L, Muller A, Browder W, Williams DL; “Effect of macrophage stimulation on collagen biosynthesis in the healing wound,” Am Surg, 63:2,125-131. Feb 1997.  Quote: “…macrophage modulation with glucan phosphate will increase tensile strength in experimental colon and skin wounds. In addition, we have observed a positive correlation between glucan phosphate treatment, wound tensile strength, and collagen biosynthesis.”

Wound Healing: Williams D.L. ,Mueller A., Mueller P., Swails  W., et. al., “Randomized phase I/II trial of a macrophage-specific immunomodulator (PGG-glucan) in high-risk surgical patients”.  Ann. Surg.; 220(5):601-609. 1994.

Wound Healing: Williams D.L., Browder I. and DiLuzio N.R., “Soluble phosphorylated glucan: methods and compositions for wound healing,”  U.S. Patent 4975421, Issued Dec 4, 1990. Quote: “The soluble phosphorylated glucans are useful for promoting the wound healing process. The soluble phosphorylated glucans are also useful for prophylactic and therapeutic applications against neoplastic, bacteria, viral, fungal and parasitic diseases.”

Wound Healing: Wolk, M. and Danon, D.; “Promotion of Wound Healing by Yeast Glucan Evaluated on Single Animals”; Medical Biology; 63:73-80. 1985.*

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