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Allergies: Talbott S, Talbott J, et al, “B-Glucan supplementation, allergy symptoms and quality of life in self-described ragweed allergy sufferers,” Food Sci Nutr; 1(1):90-101 PMCID:PMC3951572, Jan 2013: Quote: “Our findings suggest that the B-1,3/1,6-glucan can be used to decrease the symptoms of allergy in individuals with self-described ragweed allergy. ..Furthermore, they occur naturally, and are effective.”

Allergies: Yamada J, et al: “Alleviation of seasonal allergic symptoms with superfine beta-1-glucan: A randomized study.” Nippon Ganka Gakkai Zaeshi, 113(11):1082-7; PMID 19994586; Nov 2009. Quote: “Allergic response is induced by the Th2-type immune response. …The intracellular…antigen-presenting cells (APCS) reportedly regulates the Th1/Th 2 balance via distinctive cytokine production of APCs. …The double-blind, placebo-controlled randomized study shows that the ingestion of superfine dispersed beta-1,3-glucan alleviates ongoing symptoms of rhinoconjunctivitis.”

Allergies: Yamada J, Hamuro J, Hatanak H, Hamabata K, Kinoshita S: “Alleviation of seasonal allergic symptoms with superfine beta-1-glucan: A randomized study.” J of Allergy and Clinical Immunology 119(5):1119-26: PMID 17379290, Meiji U of Oriental Medicine, Kyoto, Japan; 06 2007. Quote: “It was examined whether orally ingested, superfine dispersed beta-1,3-glucan (SDG), easily absorbed by the intestinal mucosa, would alleviate allergic symptoms. Allergic patients were orally administrated …superfine dispersed beta-1,3 glucan…and allergic symptoms were assessed clinically in a double-blind, placebo-controlled randomized study. …Alleviation of allergic symptoms was evident not only for seasonal allergy to cedar pollen but also for perennial allergy. Oral ingestion of beta-1,3-glucan in individuals with allergic tropism [cells sensitive to allergens] could reduce spontaneous increase in both allergen-specific and total IgE titers.”

Allergies: Kirmaz C, Bayrak P; “Effects of glucan treatment on the Th1/Th2 [Th=Helper T cells] balance in patients with allergic rhinitis [hayfever]: a double-blind placebo-controlled study.” Eur Cytokine Netw, 20005 Jun;16(2)):128-34. PMID 15941684. Quote: “Th2-originated IL-4 and IL-5 levels responsible for the allergic inflammatory response in the microenvironment of patients with allergic rhinitis, are decreased with Glucan, while levels of Th1-originated IL-12 are increased. …eosinophils, which are important effector cells of the inflammatory response, are decreased… .” 

Asthma: Sarinho E, Medeiros D, Schor D, Silva A R, Sales V, Mottta ME, Costa A, Azoubel A, Rizzo JA; “Production of interleukin-10 [anti-inflammatory cytokine] in asthmatic children after Beta-1-3 glucan;” Allergol Immuopathol (Madr): PMID 19912977; Vol 37, Num 4:188-92,July-Aug 2009. Quote: “An experimental study carried out using a murine respiratory model detected…an increase in Interleukin-10 (IL-10 anti-inflammatory) after glucan use. This open, exploratory study with blind outcome evaluation included asthmatic children between 6 and 12 years of age with mild to moderate persistent asthma and inadequate disease control. …Beta-1-3-glucan has been proving itself to be a medication with a powerful action on interferon-gamma production, in stimulating macrophages and in its differentiation to antigen-presenting cells.

Macrophages are able of modulating the immune response because they secrete anti-inflammatory mediators such as Prostaglandin E2 (PGE-2), Tumor Growth Factor (TGE-a) and IL-10.  As such, Beta-1-3-glucan can act as a macrophage stimulant and prevent the appearance of a Th2 response. …In an animal model a single high dose of Beta-1-3-glucan has been related to an improvement in asthma and pulmonary function abnormalities.”

Conjunctivitis (Pink Eye): Lee HS, Kwon JY, Joo CK. “Topical Administration of B-1,3-Glucan to Modulate Allergic Conjunctivitis in a Murine Model.” Invest Ophthalmol Vis Sci,, 57(3), 1352-60;  PMID 27002295; Mar 2016.” Quote: “BG is capable of stimulating IL-10-producing CD4 [Helper T cells]]+ T cells and suppressing both the Th2 response in draining LNs and conjunctival eosinophil infiltration. We therefore demonstrated the therapeutic potential of topical BG administration for allergic conjunctivitis.” Note: LN refers to Lymph Nodes and BG to Beta Glucan.


 

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