โรคหลอดเลือดแดงแข็ง (Atherosclerosis) / โรคหัวใจตีบตัน (Coronary Artery Disease)

Atherosclerosis: Williams D.L., Browder I. and DiLuzio N.R., “Soluble phosphorylated glucan: methods and compositions for wound healing,”  U.S. Patent 4975421, Issued Dec 4, 1990. Quote: “Beta 1,3 glucan has proven to both stimulate and activate the macrophage cells,…People with high risk of atherosclerosis should definitely add beta 1,3 glucan to their diet in addition to any cholesterol-reducing drugs. [Atherosclerosis is a disease in which plaque builds up inside the arteries.]

Atherosclerotic Complications: DiLuzio N.R. and Williams D.L.,  “ The Roll of Glucan in the Prevention and Modification of Microparasitic Diseases;” Immunology Medicine, Alan R. Liss, Inc.; pp. 443-456. 1984. Quote: “Mindful of the extremely high rate of atherosclerotic complications and the extraordinary requirements for antioxidants  in diabetic patients, the use of beta –1,3 glucan becomes an obvious adjunct for improved lifestyle under these conditions.”

Heart – Artherogenic progression: Vetvicka V, Vetvickova J; ; “Effects of yeast-derived beta-glucans on blood cholesterol and macrophage functionality.”  U of Louisville, Dept of Pathology, Louisville, KY 40202; March 2009. Quote: “consumption of …yeast-derived beta-glucan indicated a dose-dependent decrease in plasma cholesterol levels…highly purified yeast-derived beta-glucans modify cholesterol levels and other indicators associated with artherogenic progression in mice..”

1: Scand Cardiovasc J. 2006 Oct;40(5):298-304.  Links

Heart – Coronary Artery Bypass Grafting:  Asrsaether E, Rydningen M, et al; “Cardioprotective effect of pretreatment with beta-glucan in coronary artery bypass grafting.” Dept of Cardiothoracic and Vascular Surgery, Univ Hosp of N Norway, Norway. Sand Cardiovasc J. 40(5):298-304; PubMed 17012141. Oct 2006. Quote: “The aims of the present study were to examine the safety of pretreatment with beta-1,3/1,6-glucan in patients scheduled for coronary artery bypass grafting (CABG), and to investigate whether beta-1,3/1,6-glucan pretreatment could suppress inflammatory response and protect against ischemia-reperfusion injury following CABG.  ……Twenty one patients scheduled for CABG were assigned to oral beta-1,3/1,6-glucan 700 mg (Group 1) or 1 400 mg (Group 2) five consecutive days before surgery and were compared with a control group (Group 3). Blood samples were drawn preoperatively and on the first, third and fifth postoperative day for analysis of acute-phase reactants, hematology, cytokines and myocardial enzymes. CONCLUSIONS: Beta-1,3/1,6-glucan pretreatment is safe in patients undergoing CABG [Coronary artery bypass grafting] and may protect against ischemia reperfusion injury following CABG.

Heart – Coronary Artery Disease: Robert Nicolosi, Stacey J Bell, Bruce R Bistrian, Isaac Greenberg, R Armour Forse and George L Blackburn, “Cholesterol Benefits from Beta 1,3/1,6 Glucan Purified from Yeast Cell Wall,” Nutrition and Infection Laboratory, Harvard Medical School; the Centers for the Study of Nutrition and Medicine and for Nutritional Research, and Clowes Surgical Metabolism Laboratory, Beth Israel Deaconess Medical Center, Boston. American Journal of Clinical Nutrition, Vol. 70, No. 2, 208-212, August 1999. Quote: “The purpose of this study was to evaluate the effect on serum lipids of a yeast-derived ß-glucan fiber in 15 free-living, obese, hypercholesterolemic men. … The yeast-derived ß-glucan fiber significantly lowered total cholesterol concentrations and was well tolerated…The link between elevated plasma LDL-cholesterol concentrations and the risk of developing coronary artery disease has been clearly established…Elevated plasma cholesterol and, in particular, LDL-cholesterol concentrations are associated with increased risk of coronary artery disease, whereas an elevated of HDL-cholesterol concentration is inversely correlated with the incidence of cardiovascular…The yeast-derived ß-glucan fiber lowered total cholesterol and raised HDL-cholesterol concentrations significantly. …

Unlike the significant increases in HDL-cholesterol concentrations observed 4 wk after the end of the study for subjects receiving the yeast-derived ß-glucan, none of the 24 studies of oat products reported significant changes in HDL concentration. …Because higher HDL-cholesterol concentrations are associated with a reduced risk of developing coronary artery disease, there may be unique benefits of using the yeast-derived ß-glucan, and perhaps psyllium, rather than the oat products.

Heart Disease: Carrow, D.J.; “Beta-1,3-glucan as a Primary Immune Activator,” Townsend  Letter; June 1996. Quote: “…immunosuppression is observed in people with stress-related disease such as coronary heart disease.  Under such influences the number of macrophages [white immune cells] available are reduced and unable to participate in the immune cascade, which caused an even greater immunosuppression.

 Beta 1,3 glucan has proven to both stimulate and activate the macrophage cells, which will counter these negative effects. …People with high risk of atherosclerosis should definitely add beta 1,3 glucan to their diet in addition to any cholesterol-reducing drugs.

 Macrophage activation helps draw extra cholesterol from the blood, prevent further plaque formation on the arterial walls and phagocytes [eats] existing plaque which is recognized as a foreign body.”

Heart Disease: Bell S, Goldman VM, Bistrian BR, Arnold AH, Ostroff G, Forse RA, “Effect of beta-glucan from oats and yeast on serum lipids [cholesterol included],”  Critical  Rev Food Science Nutrition, Harvard Medical School, Boston, MA; 39(2):189-202, March 1999: Quote: Heart disease is the leading cause of death in the U.S.  One way to reduce the risk of developing the disease is to lower serum cholesterol levels by making dietary changes. In addition to reducing intake of total fat, saturated fat and dietary cholesterol, serum cholesterol can be further reduced by added fiber, especially from sources rich in beta-glucan. …The yeast-derived fiber is a more concentrated source of beta-glucan than the oat product.”   

Heart – Atherosclerotic Complications: DiLuzio N.R. and Williams D.L.,  “ The Roll of Glucan in the Prevention and Modification of Microparasitic Diseases;” Immunology Medicine, Alan R. Liss, Inc.; pp. 443-456. 1984. Quote: “Mindful of the extremely high rate of atherosclerotic complications and the extraordinary requirements for antioxidants  in diabetic patients, the use of beta –1,3 glucan becomes an obvious adjunct for improved lifestyle under these conditions.”  [Atherosclerosis is a disease in which plaque builds up inside the arteries.]


 

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