ไข้หวัด (Colds/ Flu)

Colds: Stier H, Ebbeskotte V, Gruenwald J, “Immne-modulatory effects of dietary Yeast Beta 1,3/1,6-D glucan,” Nutr J 13:38, 2014. PMCID: PMC 4012169. Quote: “In contrast, a lower susceptibility to cold episodes reflects an improved defense against infections and, hence, a properly functioning immune system. Therefore, common cold is widely used as a proper model to investigate potential immune-modulating properties of natural substances, including β-glucans. …Two independent randomized, double-blind, placebo-controlled clinical trials showed that daily oral administration of the proprietary insoluble (1,3)-(1,6)-β-glucan, derived from brewers’ yeast, reduced the incidence of common cold episodes during the cold season in otherwise healthy subjects….During the most intense infection season, the β-glucan group had significantly less infections compared to placebo. Ingestion of β-glucans significantly reduced the typical cold symptoms. …The second trial with 162 participants confirmed these results, as the number of cold episodes was reduced by 25% in the β-glucan group, compared to the placebo group. Moreover, the authors reported a milder progression of severe common cold episodes in subjects supplemented with β-glucans. Also, sleeping difficulties, regarded as a side effect of a cold infection, were improved by the supplementation of β-glucan”

Colds / Pathogens: Aulinger A, Riede L, Bothe G, Busch R, Gruenwald J, “Yeast (1,3)-(1-6)-beta-glucan helps to maintain the body’s defense against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects [162]. ” Eur J Nutr, 52: 1913-1918; Jan 23, 2013. PMID 233340963. Quote: “…supplementation with insoluble yeast (1,3)-(1-6)-beta-glucan reduced the number of symptomatic common cold infections by 25% as compared to placebo. …Beta-glucan significantly reduced sleep difficulties caused by cold episode…the yeast beta-glucan preparation increased the body’s potential to defend against invading pathogens.”

Colds/Flu: McFarlin BK, Carpenter KC, Davidson T, “Baker’s yeast beta glucan supplementation increases salivary IgA [immunoglobulin] and decreases cold/flu symptomatic days after intense exercise,” J Diet Suppl  10(3):171-83, Sept 2013. PMID: 23927572. Quote: “BG [beta glucan] was associated with a 37% reduction in the number of cold/flu symptom days postmarathon compared to placebo (p = .026). In E2, BG was associated with a 32% increase in salivary IgA [immunoglobulin A].”  Note: Immunoglobulin A is an antibody that plays a critical role in immune function in the mucous membranes.

Flu/Colds: McFarlin BK, Carpenter KC, Davidson T, “Baker’s yeast beta glucan supplementation increases salivary IgA [immunoglobulin] and decreases cold/flu symptomatic days after intense exercise,” J Diet Suppl  10(3):171-83, Sept 2013. PMID: 23927572. Quote: “BG [beta glucan] was associated with a 37% reduction in the number of cold/flu symptom days postmarathon compared to placebo (p = .026). In E2, BG was associated with a 32% increase in salivary IgA [immunoglobulin A].”  Note: Immunoglobulin A is an antibody that plays a critical role in immune function in the mucous membranes.

Flu/Colds Jung K, et al, “Antiviral effect of Saccharomyces cerevisiae beta-glucan to swine influenza virus by increased production of interferon-gamma and nitric oxide,” J Vet Med B Infect Dis Vet Public Health 51(2):72-6, Mar 2004. Quote: “Saccharomyces cerevisiae beta-glucan reduced the pulmonary lesion score and viral replication rate in SIV [swine influenza virus]-infected pigs. These findings support the potential application of beta-glucan as prophylactic/treatment agent in influenza virus infection.

Flu Vaccine Adjuvant:  Wang M, Yang R, et al, “Improvement of immune response to influenza vaccine (H5N1) by sulfated yeast beta glucan,” Int J Biol Macromol, 93(Pt A) 203-207. PubMed 27339320. June 23, 2016. Quote: “The adjuvant activity of … glucan from saccharomyces cerevisiae (GSC) was researched…with inactivated H5N1 vaccine.  The research showed that GSC could significantly enhance lymphocyte [white blood cell] proliferation, effectively increase the percentage of CD4*T Cells, decrease the percentage of CD8*T Cells and elevate the CD4/CD8 ratio, enhance the Hl antibody titre, and promote the production of IL-2, INF-y, IL4 and IL-6 at medium level. …GSC could be used as an effective immune adjuvant for an inactivated H5N1 vaccine. Note: GSC is beta 1,3/1,6 glucan. CD4 and CD8 are T Helper Cells. IL2-cytokine white immune cell regulator. IL4-induces differentiation to Th2 cells.

Influenza/Colds: McFarlin BK, Carpenter KC, Davidson T, “Baker’s yeast beta glucan supplementation increases salivary IgA [immunoglobulin] and decreases cold/flu symptomatic days after intense exercise,” J Diet Suppl  10(3):171-83, Sept 2013. PMID: 23927572. Quote: “BG [beta glucan] was associated with a 37% reduction in the number of cold/flu symptom days postmarathon compared to placebo (p = .026). In E2, BG was associated with a 32% increase in salivary IgA [immunoglobulin A].”  Note: Immunoglobulin A is an antibody that plays a critical role in immune function in the mucous membranes.

Influenza/Colds Jung K, et al, “Antiviral effect of Saccharomyces cerevisiae beta-glucan to swine influenza virus by increased production of interferon-gamma and nitric oxide,” J Vet Med B Infect Dis Vet Public Health 51(2):72-6, Mar 2004. Quote: “Saccharomyces cerevisiae beta-glucan reduced the pulmonary lesion score and viral replication rate in SIV [swine influenza virus]-infected pigs. These findings support the potential application of beta-glucan as prophylactic/treatment agent in influenza virus infection.

Influenza Vaccine Adjuvant:  Wang M, Yang R, et al, “Improvement of immune response to influenza vaccine (H5N1) by sulfated yeast beta glucan,” Int J Biol Macromol, 93(Pt A) 203-207. PubMed 27339320. June 23, 2016. Quote: “The adjuvant activity of … glucan from saccharomyces cerevisiae (GSC) was researched…with inactivated H5N1 vaccine.  The research showed that GSC could significantly enhance lymphocyte [white blood cell] proliferation, effectively increase the percentage of CD4*T Cells, decrease the percentage of CD8*T Cells and elevate the CD4/CD8 ratio, enhance the Hl antibody titre, and promote the production of IL-2, INF-y, IL4 and IL-6 at medium level. …GSC could be used as an effective immune adjuvant for an inactivated H5N1 vaccine. Note: GSC is beta 1,3/1,6 glucan. CD4 and CD8 are T Helper Cells. IL2-cytokine white immune cell regulator. IL4-induces differentiation to Th2 cells.


 

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